Gene-Environment Interaction in Healthy Brain Ageing and Age Related Neurodegeneration

Identification of blood eQTLs in older adults

A Toyin, KA Mather, NJ Armstrong, LG Ciobanu, BT Baune, JB Kwok, PR Schofield, D Ames, JN Trollor, PS Sachdev, A Thalamuthu

2025-04-20

Genome-wide association studies (GWAS) have been successful in identifying genetic variation associated with a wide range of pheno..

Brain-age prediction: Systematic evaluation of site effects, and sample age range and size

Y Yu, HQ Cui, SS Haas, F New, N Sanford, K Yu, D Zhan, G Yang, JH Gao, D Wei, J Qiu, N Banaj, DI Boomsma, A Breier, H Brodaty, RL Buckner, JK Buitelaar, DM Cannon, X Caseras, VP Clark

2024-07-15

Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain-age) which has been a..

Heritability of Gene Expression Measured from Peripheral Blood in Older Adults

SC Kanchibhotla, KA Mather, NJ Armstrong, LG Ciobanu, BT Baune, VS Catts, PR Schofield, JN Trollor, D Ames, PS Sachdev, A Thalamuthu

2024-04-01

The contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies..

Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers

R Boen, T Kaufmann, D van der Meer, O Frei, I Agartz, D Ames, M Andersson, NJ Armstrong, E Artiges, JR Atkins, J Bauer, F Benedetti, DI Boomsma, H Brodaty, K Brosch, RL Buckner, MJ Cairns, V Calhoun, S Caspers, S Cichon

2024-01-15

Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences c..

Genetic and environmental influences on fruit and vegetable consumption and depression in older adults

Annabel PP Matison, Anbupalam Thalamuthu, Victoria MM Flood, Julian NN Trollor, Vibeke SS Catts, Margaret JJ Wright, David Ames, Henry Brodaty, Perminder SS Sachdev, Simone Reppermund, Karen AA Mather

2023-02-03

BACKGROUND: Prior work suggests that higher fruit and vegetable consumption may protect against depression in older adults. Better..

High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile

M Revelas, A Thalamuthu, A Zettergren, C Oldmeadow, J Najar, NM Seidu, NJ Armstrong, C Riveros, JB Kwok, PR Schofield, JN Trollor, M Waern, MJ Wright, H Zetterberg, D Ames, K Belnnow, H Brodaty, RJ Scott, I Skoog, JR Attia

2023-02-01

Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and negative ..

Financial strain moderates genetic influences on self-rated health: support for diathesis–stress model of gene–environment interplay

D Finkel, C Zavala, CE Franz, S Pahlen, M Gatz, NL Pedersen, BK Finch, A Dahl Aslan, VS Catts, M Ericsson, RF Krueger, NG Martin, A Mohan, MA Mosing, CA Prescott, KE Whitfield

2022-01-01

Data from the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium were used to examine predictions of di..

The heritability of amyloid burden in older adults: the Older Australian Twins Study

R Koncz, A Thalamuthu, W Wen, VS Catts, V Dore, T Lee, KA Mather, MJ Slavin, EA Wegner, J Jiang, JN Trollor, D Ames, VL Villemagne, CC Rowe, PS Sachdev

2022-01-01

Objective To determine the proportional genetic contribution to the variability of cerebral β-amyloid load in older adults using t..

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

IE Sønderby, D van der Meer, C Moreau, T Kaufmann, GB Walters, M Ellegaard, A Abdellaoui, D Ames, K Amunts, M Andersson, NJ Armstrong, M Bernard, NB Blackburn, J Blangero, DI Boomsma, H Brodaty, RM Brouwer, R Bülow, R Bøen, W Cahn

2021-06-01

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopme..

Investigating Olfactory Gene Variation and Odour Identification in Older Adults

Siddharth Raj, Anbupalam Thalamuthu, Nicola J Armstrong, Margaret J Wright, John B Kwok, Julian N Trollor, David Ames, Peter R Schofield, Henry Brodaty, Perminder S Sachdev, Karen A Mather

2021-05-01

Ageing is associated with a decrease in odour identification. Additionally, deficits in olfaction have been linked to age-related ..

Downregulated transferrin receptor in the blood predicts recurrent MDD in the elderly cohort: A fuzzy forests approach

LG Ciobanu, PS Sachdev, JN Trollor, S Reppermund, A Thalamuthu, KA Mather, S Cohen-Woods, D Stacey, C Toben, KO Schubert, BT Baune

2020-04-15

Background: At present, no predictive markers for Major Depressive Disorder (MDD) exist. The search for such markers has been chal..

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

NL Pedersen, M Gatz, BK Finch, D Finkel, DA Butler, A Dahl Aslan, CE Franz, J Kaprio, S Lapham, M McGue, MA Mosing, J Neiderhiser, M Nygaard, M Panizzon, CA Prescott, CA Reynolds, P Sachdev, KE Whitfield

2019-12-01

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countri..

Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults

LG Ciobanu, PS Sachdev, JN Trollor, S Reppermund, A Thalamuthu, KA Mather, S Cohen-Woods, D Stacey, C Toben, KO Schubert, BT Baune

2018-12-01

The molecular factors involved in the pathophysiology of major depressive disorder (MDD) remain poorly understood. One approach to..

Genome-wide average DNA methylation is determined in utero

S Li, EM Wong, PA Dugué, AF McRae, E Kim, JHE Joo, TL Nguyen, J Stone, GS Dite, NJ Armstrong, KA Mather, A Thalamuthu, MJ Wright, D Ames, RL Milne, JM Craig, R Saffery, GW Montgomery, YM Song, J Sung

2018-06-01

Background: Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a globa..

Incidental findings on cerebral MRI in twins: the Older Australian Twins Study

R Koncz, A Mohan, L Dawes, A Thalamuthu, M Wright, D Ames, T Lee, J Trollor, W Wen, P Sachdev

2018-06-01

Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence inc..

Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study

T Lee, A Thalamuthu, JD Henry, JN Trollor, D Ames, MJ Wright, PS Sachdev

2018-05-01

We used a sub-sample from the Older Australian Twins Study to estimate the heritability of performance on three tests of language ..

Novel genetic loci underlying human intracranial volume identified through genome-wide association

HHH Adams, DP Hibar, V Chouraki, JL Stein, PA Nyquist, ME Rentería, S Trompet, A Arias-Vasquez, S Seshadri, S Desrivières, AH Beecham, N Jahanshad, K Wittfeld, SJ Van Der Lee, L Abramovic, S Alhusaini, N Amin, M Andersson, K Arfanakis, BS Aribisala

2016-12-01

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late ..

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

MK Lupton, L Strike, NK Hansell, W Wen, KA Mather, NJ Armstrong, A Thalamuthu, KL McMahon, GI de Zubicaray, AA Assareh, A Simmons, P Proitsi, JF Powell, GW Montgomery, DP Hibar, E Westman, M Tsolaki, I Kloszewska, H Soininen, P Mecocci

2016-04-01

Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's ..

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

KA Mather, A Thalamuthu, C Oldmeadow, F Song, NJ Armstrong, A Poljak, EG Holliday, M McEvoy, JB Kwok, AA Assareh, S Reppermund, NA Kochan, T Lee, D Ames, MJ Wright, JN Trollor, PW Schofield, H Brodaty, RJ Scott, PR Schofield

2016-03-31

Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH lev..

Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept

B Franke, KJE van Hulzen, A Arias-Vasquez, J Bralten, M Hoogman, M Klein, MMJ van Donkelaar, MMH Hakobjan, AJGAM Heister, RRR Makkinje, MAM Naber, SSL van der Marel, JC Mostert, HG Brunner, H van Bokhoven, MP Zwiers, JK Buitelaar, G Fernández, SE Fisher, C Francks

2016-02-23

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, betwee..

Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals

CJ Boraxbekk, D Ames, NA Kochan, T Lee, A Thalamuthu, W Wen, NJ Armstrong, JBJ Kwok, PR Schofield, S Reppermund, MJ Wright, JN Trollor, H Brodaty, P Sachdev, KA Mather

2015-11-01

The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic..

Investigating the genetics of hippocampal volume in older adults without dementia

KA Mather, NJ Armstrong, W Wen, JB Kwok, AA Assareh, A Thalamuthu, S Reppermund, K Duesing, MJ Wright, D Ames, JN Trollor, H Brodaty, PR Schofield, PS Sachdev

2015-01-27

Hippocampal atrophy is observed with ageing and age-related neurodegenerative disease. Identification of the genetic correlates of..

DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals

J Lazarus, KA Mather, NJ Armstrong, F Song, A Poljak, A Thalamuthu, T Lee, NA Kochan, H Brodaty, MJ Wright, D Ames, PS Sachdev, JBJ Kwok

2015-01-01

Background: DNA methylation variation has been implicated in memory, cognitive performance, and dementia. Plasma apolipoprotein-A1..

Genetics of microstructure of the corpus callosum in older adults

SC Kanchibhotla, KA Mather, A Thalamuthu, L Zhuang, PR Schofield, JBJ Kwok, D Ames, MJ Wright, JN Trollor, W Wen, PS Sachdev

2014-12-01

The current study sought to examine the relative influence of genetic and environmental factors on corpus callosum (CC) microstruc..

Leisure activity, health, and medical correlates of neurocognitive performance among monozygotic twins: The older Australian twins study

T Lee, DM Lipnicki, JD Crawford, JD Henry, JN Trollor, D Ames, MJ Wright, PS Sachdev

2014-01-01

Objectives. We aimed to examine associations between each of three leisure activities (Cognitive, Physical, and Social) and perfor..

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

S Reyes, Y Fu, KL Double, V Cottam, LH Thompson, D Kirik, G Paxinos, C Watson, HM Cooper, GM Halliday

2013-03-01

Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the..

Genetic influences on five measures of processing speed and their covariation with general cognitive ability in the elderly: The older Australian twins study

T Lee, MA Mosing, JD Henry, JN Trollor, A Lammel, D Ames, NG Martin, MJ Wright, PS Sachdev

2012-01-01

Processing speed (PS) is one of the basic elements of cognitive functions and has been regarded as a "common mechanism" which medi..

Genetic influences on four measures of executive functions and their covariation with general cognitive ability: The Older Australian Twins Study

T Lee, MA Mosing, JD Henry, JN Trollor, D Ames, NG Martin, MJ Wright, PS Sachdev

2012-01-01

"Executive functions" (EF) is a multidimensional construct which encompasses many higher-order cognitive control operations, and i..